The effect of hydro-alcoholic extract of fumaria officinalis leaf on pain and seizure by pentylentetrazole-induced mice

There are many reports for mutual mechanisms for seizure and pain alleviation. Also with respect to the herbal medicine recommendation in new medicine, in this study we used the extract of an important candidate fumaria officinal for relief of pain and seizure in mice.

In our experiments 40 mice were divided to 5 groups (n=8): 1-control 2- positive control and three groups of extract treatment respectively 200, 600 and 800 mg/kg. All of the animal groups were conducted to formalin and tail immersion tests for assessment of pain and finally seizure analysis were done by injection of PTZ (100 mg/kg) to the animals and initiation time (s) for myoclonus, clonus and the tonus signs were measured for seizure analysis.

Our results indicated that the extract in three doses (200, 600 and 800 mg/kg) can reduced the formalin acute and chronic pain. Also the start time for seizure signs i.e, myoclonus, clonus and seizures could elevated markedly in lower doses of the extract (200 and 600 mg/kg).

In addition, treatment of the mice with hydroalcoholic extract of fumaria officinalis leaf could significantly reduce the acute and chronic pain and increase the initiation time of the seizure signs.