Fabrication and Investigation of Toxicity of CuFe2O4 Nanoparticles Synthesized by Combustion Sol-Gel Method for Hyperthermia Application

Magnetic nanoparticles have attracted a lot of attention due to their unique chemical and physical properties and their use in medical applications such as hyperthermia. In this research, copper ferrite nanoparticles were synthesized by combustion gel-sol method. The synthesized samples were studied by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, nitrogen adsorption and desorption test (BET), energy dispersive spectroscopy (EDS), scanning electron microscopy (FESEM) and vibrational sample magnetometry (VSM). The average crystal size was about 25 ± 8 nm and its specific surface area was about 2.59±0.20 m2/g. Morphology and shape of nanoparticles were spherical and the average size of copper ferrite nanoparticles was about 96 ± 10 nm. Copper ferrite has ferromagnetic properties and saturation magnet was obtained at about 29.28 emu/g. the release of ibuprofen from these nanoparticles was investigated. Cytotoxicity of the nanoparticles on HT29 cancer cells was evaluated. CuFe2O4 copper ferrite nanoparticles were also analyzed by hypothermia method. The results showed a rise in temperature to about 42 ° C and a specific adsorption rate of 9.62 W/g.