Fibrinogen Dysregulation is a Prominent Process in FatalConditions of COVID-19 Infection; a Proteomic Analysis

Molecular pathophysiology of COVID-19 is not completely known. Expression changes in pa-tients’ plasma proteins have revealed new information about the disease. Introducing the key targeted plasmaprotein in fatal conditions of COVID-19 infection is the aim of this study.

Significant differentiallyexpressed proteins (DEPs) in the plasma of cases with a fatal condition of COVID-19 were extracted from anoriginal article. These proteins were included in a network via STRING database along with 100 first neighborproteins to determine central nodes of the network for analyzing.

Queried and added proteins wereincluded in a scale free network. Three hub nodes were identified as critical target proteins. The top queriedhub proteins were chains of fibrinogen; Fibrinogen Alpha chain (FGA), Fibrinogen gamma chain (FGG), andFibrinogen beta chain (FGB), which are related to the coagulation process.

It seems that fibrinogendysregulation has a deep impact on the fatality of COVID-19 infection.