Early exercise training attenuates cystatin C and carbohydrate antigen 125 levels after myocardial infarction in rats

The aim of the study to evaluate the impact of aerobic training on cardiometabolic and inflammatory changes evoked by myocardial infarction in rats.

In this experimental study, two-month-old male Wistar rats were infarcted and randomly divided into two groups with n = 11 in each group: sedentary +MI (MI+S) and aerobic training +MI (MI+EX). After the acclimatization period, ISO (85mg/kg) was subcutaneously injected into the rats at 24 h intervals for 2 days. ISO-induced myocardial damage was indicated by increased serum cardiac-specific troponin I levels and ST-segment elevation. The MI+EX rats were conditioned to run on a treadmill for 10 weeks. 48 hours after the last training session, a venous sample was collected to determine metabolic parameters, including carbohydrate antigen 125 and cystatin C. The independent t-test was applied to analyze the data (P<0.05).

As predicted, the MI+S group had an increase in carbohydrate antigen 125 (P=0.03), cystatin c (P=0. 01), and troponin-I (P=0.002) concentrations. Unlike the MI+S group, in the MI+EX group carbohydrate antigen 125 (P=0.01), cystatin C (P=0.04), and maximal treadmill exercise test (P=0.01) were improved.

Our findings suggest that early aerobic training may be useful in preventing the negative changes in functional, inflammatory, and metabolic parameters related to MI.