The Effect of Chemotherapy in Gestational Trophoblastic Disease onInfertility: A Review on Pathophysiologic Mechanism

Today, young women infertility through chemotherapy has become a global challenge. Chemotherapy destructs the malignant cells by reactive oxygen species (ROS)productionand inflammatory factorssecretion; these factors can also destructthe ovarian and uterine cells. Infertility usuallyhappens as a result of ovarian and uterine cellsapoptosis, as well as dysfunctionin these organs. Signaling pathways activated by chemotherapy lead to increased activation of follicles and depletion of the follicular pool. In addition, excessive secretion of sex hormones leads to follicles activation and infertility in women. Mesenchymal stem cells(MSC) use havebeen reported to be a great help inrestoringthe function of ovarian and uterine cells.On the other hand, theycanregulate sex hormonesecretion. Finally, the use of MSCsas a suitable treatment strategy can help restore the function of reproductive cells and treat infertility.