Effects of hydro-alcoholic leaf extract of Kardeh (Biarum bovei Blume) on the blood glucose and oxidative stress parameters in streptozotocin-induced diabetic rats

Oxidative stress is the result of an imbalance between the production of free radicals and the bodychr('39')s antioxidant defense. Using antioxidants can have preventative effects on diabetes. The present study aimed to evaluate the effects of aqueous extract of Kardeh on blood glucose and oxidative stress parameters in streptozotocin-induced diabetic rats.

In this study, 40 male Wistar rats weighing 250 ± 200 g were selected and randomly divided into 5 groups (control, diabetic, treatment (diabetic + receiving biarum bovei hydroalcoholic extract of the plant at doses of 100, 200 and 400 mg / kg body per day by gavage for 14 days)). At the end of the study period, fasting blood glucose as well as malondialdehyde levels and the activity of antioxidant enzymes superoxide dismutase, glutathione peroxidase and catalase heart tissue were evaluated. The collected data were analyzed by SPSS software using one-way analysis of variance.

The results showed that serum glucose concentration in the treatment group was significantly lower than the diabetic group (P<0.01). Also, in the treatment group, the level of MDA was significantly lower and the activity of TAC, SOD and GPX enzymes was higher than the diabetic group.

The results of the present study showed that Kardeh hydroalcoholic extract is able to prevent hypertension in diabetic rats and strengthen the antioxidant system of heart tissue.