Effects of Escitalopram on sex steroids and oocyte ultrastructure in three spot Gourami after increasing dopamine level by Bromocriptine injection

In this study, we aimed to investigate the effect of serotonin on the lower levels of HPG by blocking the upper HPG axis.90 pieces of three spot Gourami fish with an average weight of 3±1 gram were bought from the Khanmahi fish breeding center. The fish were divided into 6 groups. Intact Control group, solvent (Ethanol 70º) group, bromocriptine control and 3 treatment group received bromocriptine and escitalopram in three doses of 1,5 and 10 milligram per kilogram body weight. The injection was given intramuscular (IM) every other day. The fish were dissected and ovarian tissues dissected for light and electron microscope. After tissue fluids preparation, steroid hormones were measured with a special kit. Based on the results of the second dose of escitalopram and bromocriptine which was the predominant stage of vitellogenesis and gonadal index, it can be concluded that serotonin receptor may be present at the lower levels of the HPG axis.