Effects of Pulegone in Cutaneous Lesions of Experimental Pseudomoniasis in goat

The issue of antibiotic resistance is currently being pursued very seriously. One of the drug-resistant bacteria is Pseudomonas aeruginosa. As an opportunistic and important pathogen in human and livestock, this bacterium can be resistant to various antibiotics in different ways. For thisreason, research to obtain antimicrobials from alternative sources such as plants and plant essential oils is considered by many researchers. This study investigated the antimicrobial potentials and therapeutic effects of pulegone in experimental cutaneous pseudomoniasis in goats clinically.

Four two-year-old female goats weighing approximately 45 kg were used. To prepare the P. aeruginosa inoculation site, the right and left chest and the flank on both sides of the animal were shaved to an area of 30 cm2 at each site. After supressing the immune system by injection of dexamethasone, in each place at five points and at each point 0.4 ml of P. aeruginosa suspension, was injected intradermally. After cutaneous pseudomoniasis induction, lesions in the right thoracic region were treated with glycerol-soluble pulegone, lesions in the left thoracic region were treated with gentamicin ointment as standard treatment, and lesions in the right thoracic region were treated daily with glycerol. Lesions in the left flank were not treated as a control group.

The results of this study showed that pulegone, just like gentamicin, treats goat cutaneous pseudomoniasis wounds in nine days and heals them effectively.