Clinical Complications and Laboratory Disturbances Following Administration of Intravenous Immunoglobulin (IVIG) in hospitalized Children in Imam Hossein Hospital, Isfahan, Iran, in Years 2018-2019

Intravenous immunoglobulin (IVIG) is a product isolated from the plasma of donors. Laboratory variations are one of the complications of this product. The goal of this study was to evaluate the adverse effects and laboratory variations in children receiving IVIG.

This retrospective cross-sectional study was conducted by studying the file records of all admitted patients receiving IVIG in Imam Hossein Hospital, Isfahan, Iran, in years 2018-2019. Then, all registering data in collection form were entered into SPSS software, and relevant analysis was performed.

Serum sodium, potassium, and hemoglobin reduced significantly. Blood urea nitrogen (BUN) level increased after infusion. However, changes in albumin and creatinine were not statistically significant. 3 patients (16.67%) developed fever, chills, and headache after infusion. No reduction in urinary output, or acute renal failure was observed in any of patients.

The laboratory variations are not clinically dangerous in patients. Follow-up tests are not routinely recommended for all patients.