Effect of high-fat diet on oxidative stress and testicular function in male rabbits and protective effect of silver nanoparticles and Moringa oleifera

This study aimed to evaluate the effect of silver nanoparticles and Moringaleaf extract on testicular histology and antioxidants parameters after a high-fat diet exposure in male rabbits. The experiment was conducted on 30 male white rabbits, which were assigned into 6 experimental groups. The levels of Malondialdehyde (MDA) andthe diameter of seminiferous tubules and germinalepitheliumthickness were examined and compared. In blood serum of rabbits fed a high-fat diet noted an increased level of MOD. The addition of silver nanoparticles and Moringaleaf extract to the diet decreased the MOD level showed a beneficial effect. Rabbits fed a high-fat diet had a significant reduction in the diameter of seminiferous tubules and a decrease in the thickness of the germinalepithelium. The reduction was induced by supplementation with silver nanoparticles and Moringaleaf extract. Considering these results, it was possible to assume that exposure to silver nanoparticles and Moringaleaf extract have a possible protective effect on the reproductive system of male rabbits.