The effect of two types of continuous and interval cardiac rehabilitation on serum VEGF and endostatin in Male cardiac patients after coronary angioplasty (PCI)

Angiogenesis is a critical process in tissue growth and development, especially in muscle tissue that is affected by muscle contraction. The development of the angiogenesis process in cardiac patients is crucial. For this the aim of this study was to investigate the effect of two types of continuous and interval cardiac rehabilitation training program on serum VEGF and Endostatine after coronary angioplasty (PCI) in Male cardiac patients.

Thirty patients were randomly divided into three (aerobic, interval and control) groups. Two training groups trained for eight weeks according to their own protocol. Fasting blood sample was taken from the groups 48 hours before and after the training protocol. Serum VEGF and ES were measured by ELISA kit. To analyze the data, repeated measures ANOVA test was used and when differences was significant Bonferroni post hoc test was used to define the place of deference.

The results of this study showed that performing continuous and interval training increased VEGF level and decreased Endostatin significantly compared to the control group. Endostatin decline was more pronounced in the interval exercise training group.

Interval training can be used as a safe and effective method during cardiac rehabilitation like aerobic training method. It can even be concluded that interval exercise was more effective in reducing the inhibitory pathway of angiogenesis.