The Role of Tranexamic Acid in Reducing Blood Loss Following Total Joint Arthroplasty: A Review Article

Total Joint Arthroplasty (TJA) is a major surgery performed for patients who suffer from severe joint destruction. It is so important to reduce the blood loss in the TJA surgery to decrease the infection rate, falling, and other complications following the surgery. Many methods could reduce blood loss, such as mechanical methods and chemical methods. Tranexamic acid (TXA) is a chemical method to reduce blood loss in surgery. There are numerous methods of administration of TXA in the literature, such as intravenous (IV), intra-articular, and a combination of intra-articular and -venous methods. In the present review article, we review the studies that compared the efficacy of each method of the TXA administration.