Simultaneous Effect of Resistance Training and Stem Cell Injection on Blood Glucose Levels, Insulin Resistance, Caspase 3 And 7 As Indicators of Skeletal Muscle Apoptosis in STZ-Induced Male Diabetic Rats

The aim of the present study was to investigate the simultaneous effect of resistance training and stem cell injection on the levels of some indicators of skeletal muscle apoptosis in STZ-induced diabetic male rats.

In this study, 30 rats were randomly divided into 5 groups. Rats in the diabetic group and the diabetic group + stem cell injection had a total of 17 sessions of resistance training for 5 weeks. The training period for rats with this type of training was 3 days, which was done 48 hours before STZ injection. Western blotting was used to evaluate the changes in Caspase7 and caspase3. The data were analyzed using two-factor analysis of variance test with SPSS software version 19 at a significance level of α≤ 5%.

The results of the present study showed that there was no significant difference between the mean of caspase3 in the resistance training group with simultaneous injection of stem cells and the training group. Also, resistance training with simultaneous injection of endothelial stem cells, compared to resistance training or injection alone, led to a significant reduction in Caspase7 expression in skeletal muscle tissue of diabetic rats.

Based on the results of this study, it can be stated that resistance training or injection of endothelial progenitor cells can stimulate apoptosis in skeletal muscle.