Green synthesis of gold nanoparticles with beet extract and investigation of its anti-cancer properties

In this study, the synthesis of gold nanoparticles and its anti-cancer properties were studied. In order to obtain gold nanoparticles with morphology, appropriate size and stability of microwave, sonochemical and green synthesis methods using HAuCl4, tri sodium citrate, PVP (polyvinylpyrrolidine), chitosan and beet extract were used. Morphology, uniform distribution and the size of nanoparticles synthesized by XRD, SEM, FT-IR, UV-Vis and TEM devices were studied. Nanoparticles are easily introduced in to cancer cells, which is why the nanoparticles synthesized by this method for experiments involving the interaction of gold nanoparticles with DNA of the calf thymus gland DNA (CT-DNA) using UV-Vis spectroscopy technique in trace buffer containing chloride Sodium (10 mM) and pH = 7 at 300 K were studied. The cytotoxicity studies of gold nanoparticles by MTT on the breast cancer cell line (MCF-7) showed Ic50 of gold nanoparticles of 24.1. Therefore, these nanoparticles are capable of inhibiting the activity, growth and proliferation of cancerous cells at low concentrations