INVESTIGATING THE RELATIONSHIP BETWEEN URINARY AND SERUM LDH WITH THE SEVERITY OF CORTICAL INVOLVEMENT IN ACUTE PYELONEPHRITIS

Urinary tract infection is one of the most common childhood infections that can occur in the lower parts of the urinary tract as cystitis and the upper parts and renal parenchyma as pyelonephritis. The aim of this study was to determine the relationship between urinary and serum LDH levels with the severity of cortical involvement in DMSA in children with acute pyelonephritis.

In this cross-sectional (descriptive-analytical) study, all patients with pyelonephritis who were admitted to the nephrology department for the first time with this diagnosis in 2018 were included in this study. The severity of renal involvement in the DMSA scan was defined as follows: grade I= equivocal, grade II =one area, grade III = more than two, and grade IV = global. Urine samples were maintained in the appropriate temperature and up to half an hour after sampling were sent to the laboratory for U/A, U/C, and measurement of urinary LDH. Normal urinary LDH was 4-9 mU / ml with a mean of 10.8 ± 1. Serum LDH was sent at the beginning of hospitalization at the same time as the first blood draw during the first 24 hours.

The mean age of patients in this study was 3.85 ± 2.79 years. The majority of patients were girls (95.7%). The mean serum level of LDH in patients was 465.81 ± 153.05 and the urinary level of LDH was 28.68 ± 22.45. There was no significant difference between subjects with different grades in terms of urinary and serum levels (p <0.05).

The results of this study showed that there is no significant relationship between serum and urinary LDH levels with the severity of renal cortical involvement in patients with acute pyelonephritis.