Investigation of the role of microRNAs in the regeneration of damaged organs in zebrafish

The tissue regeneration due to its attractive nature and potential applications in human diseases has always been in the focus of research. Determining the cellular and molecular mechanisms involved in the regeneration process in model organisms that perform well regeneration can help us to developing strategies for tissue repair and regeneration in species such as humans that have low regenerative capacity. MicroRNAs, are small, non-coding RNAs that play a key role in controlling the expression of genes that conduct tissue regeneration by inducing overexpression or inhibition. Various experiments have been performed to identify the types of microRNAs that conducte regenerative responses. Due to the exceptional ability of the zebrafish (Danio rerio) in the process of self-healing of damaged tissues, this model has been considered as the focus of regeneration researches. In this article, we intend to review the latest findings on the effect of microRNAs on the fin, heart and eye regeneration process of zebrafish by regulating gene expression. The future prospects and further development potential of this fascinating research field will also be discussed.