The Relation Between Non-alcoholic Fatty Liver Disease and the Risk of Coronary Heart Disease

The prevalence of non-alcoholic fatty liver disease (NAFLD) is about 30% in general population. Since conditions such as obesity, hyperlipidemia, diabetes mellitus, metabolic syndrome and insulin resistance have been named as some of the most important risk factors, as the prevalence of these conditions continues to rise, NAFLD becomes an increasingly significant problem. Endothelial dysfunction, increased pulse wave velocity, increased coronary artery calcification, and the development of atherosclerosis appear to be influenced by NAFLD. Considering this concern, this narrative review investigated the prevalence of CVD in NAFLD patients.

This narrative study evaluates the prevalence of CVD in NAFLD patients, as well as several variables that influence their association. In this study our search strategy engines include PubMed, Scopus, MEDLINE, and Google Scholar.

Previous research suggests that as nonalcoholic steatohepatitis (NASH) and liver fibrosis progress, there is an increased risk of CVD, most likely due to the hepato-cardiovascular axis’ effect. The correlation between NAFLD and metabolic disorders suggests that fatty liver disease may cause cardiovascular disorders (CVD).

As a result, the management of both NAFLD and the risk of CVD are aimed at the same target, which is to reduce insulin tolerance by lifestyle modifications. Moreover, monitoring for CVD and proper pharmacotherapy is essential in individuals with severe NAFLD and those who are at increased risk for ischemic heart disease.