New Insights in the Use of Boron Nitrogen Nanotubes as Cisplatin Nanovector

The drug nano-vectorization is one of the objective priorities of modern medicine. A DFT study that concerns inclusion complexes between the anticancer drug cisplatin and boron nitrogen nanotubes (BNNTs) whose diameters vary from 7.35 to 12.87Ǻ is presented in this paper. The objective of the first part of the work was to highlight the different quantum phenomena that can control the chemical or physical absorption of cisplatin at the nanometric scale. The second part dealt with Nuclear Magnetic Resonance (NMR) studies that allowed the establishment of a relationship between the chemical shift (δ) of the central platinum (195 Pt) atom of the cisplatin molecule and the diameter of the used BNNT. This result can be used to monitor the concentration of cisplatin during drug filling and delivery. Finally, at a fixed diameter of the nanotube, we studied the influence of encapsulation of several cisplatin molecules and the solvent effect. We hope that this study will help in making an informed decision while choosing the diameter, the type, and length of nanotubes, based on the curative dose to be delivered to minimise drug toxicity.