Effects of Vitamin D3 Fortified Low-fat Dairy Products on Bone Density Measures in Adults with Abdominal Obesity: A Randomized Clinical Trial
Payam Sharifan , Elahe Hassanzadeh , Maryam Mohammadi-Bajgiran , Vahid Reza Dabbagh , Elham Aminifar , Hamideh Ghazizadeh , Sara Saffar-Soflaei , Susan Darroudi , Davoud Tanbakouchi , MohammadReza Fazl-Mashhadi , Ali Ebrahimi-Dabagh , MohammadAmin Mohammadi , Anahid Hemmatpur , Gordon A. Ferns , Habibollah Esmaily , Ramin Sadeghi , Majid Ghayour-Mobarhan *
Bone disease-related fractures constitute a heavy burden on the healthcare systems and economy.Vitamin D is an important regulator of bone health and its deficiency is a global problem. This study aimed to evaluatethe effect of the 1,500 IU nano-encapsulated vitamin D used for fortifying low-fat dairy products (milk and yogurt) onbone health parameters.
This parallel totally blinded, randomized controlled trial was part of the Ultraviolet Intake by NutritionalApproach study and conducted on 306 individuals with abdominal obesity. Individuals were randomly assigned tofour groups, including fortified low-fat milk (1,500 IU nano-encapsulated vitamin D3 per 200 g/d), non-fortified low-fatmilk, fortified low-fat yogurt (1,500 IU nano-encapsulated vitamin D3 per 150 g/d), and non-fortified low-fat yogurt,for 10 weeks between January and March 2019. Bone mineral density (BMD) and trabecular bone score (TBS) weremeasured at the baseline and end of the trial. Trabecular bone score and BMD were defined as primary and secondaryoutcomes.
There were no significant differences in TBS and BMD between the intervention and control groups at theend of the trial (P>0.05).
This trial demonstrated no significant effect of nano-encapsulated vitamin D fortified milk and yogurt onBMD and TBS. There remains a need for longer-term trials regarding bone health outcomes to establish optimal dosesof fortification.Level of evidence: I
BMD , bone health , fortification , TBS , Vitamin D3
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.