DEMONSTRATION OF LOCAL ANTITOXOPLASMIC IMMUNOGLOBULIN G PRODUCTION IN OCULAR TOXOPLASMOSIS, TRACED BY ENZYME IMMUNOASSAY OF AQUEOUS HUMOR AND SERUM

Forty patients with cataracts, as well as 40 patients with proven ocular toxoplasmosis were enrolled in this prospective clinical study. Serum IgG and aqueous IgG in both groups were measured by enzyme-linked immunosorbent assay (ELISA) and the corresponding ratios were calculated. Serum IgG/aqueous humor IgG ratio was less than 100 in the patient group and more than 100 in the control group. On the other hand in the chorioretinitis subgroup the ratio was less than 13, while in the group With uveitis, the ratio was more than 13 (p<0.05). The results revealed that calculating the ratio of Serum IgG (antitoxo) / Aqueous IgG (antitoxo) may be helpful as an adjunct to diagnosis in cases with clinically atypical ocular toxoplasmosis.