Investigating the Antimicrobial Activity of Peperin Isolated from Black Pepper on Staphylococcus Aureus Isolated from the Throat and Nose

Due to the increasing resistance of pathogenic bacteria to common antibiotics, researchers are looking for antimicrobial agents of plant origin as alternative drugs. The aim of this study is to investigate the antimicrobial activity of peperin isolated from black pepper on Staphylococcus aureus isolated from the nose and throat. Sampling was done from the pharynx and nose of the patients and 9 strains of Staphylococcus aureus were isolated and purified. The minimum inhibitory concentration (MIC) and the minimum lethal concentration (MBC) in six concentrations were evaluated by dilution method in liquid medium on the determined bacteria. The results of this study showed that the lowest inhibitory concentration was equal to 8 μg/ml, which inhibited one strain, while the highest concentration was 512 μg/mg, which inhibited one strain. Staphylococcus aureus isolated the most It was resistant to trimethoprim (88.8%), ampicillin (77.7%), tetracycline (77.7%), erythromycin (66.6%) and ceftazidime (22.2%). The results of this study showed that piperine present in black pepper has a very strong inhibitory effect on Staphylococcus aureus bacteria isolated from the nose and throat.