The effect of different intensities of chronic aerobic training on changes in liver index enzymes in patients with non-alcoholic fatty liver disease in men and women with different ages, systematic review and meta-analysis

Several studies have examined the effect of chronic aerobic training on factors associated with non-alcoholic fatty liver disease. The aim of this study was to determine the effect of different intensities of chronic aerobic training (low, medium and high) on alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma glutamine transferase in men and women of different ages. Done in 1400. Databases, ScienceDirect, PubMed, Scopus and Google Scholar were searched along with keywords. A total of 120 non-review articles with appropriate quality of aerobic training were reviewed and 22 articles were meta-analyzed. Accordingly, 1560 people with an average (52 ± 10 years) Fatty liver disease was examined. The effects of the intervention were evaluated using SMD and stochastic effects model. In the results of meta-analysis of aerobic training in general with any intensity significantly reduces the levels of aspartate aminotransferase, alkaline phosphatase and gamma glutamine transferase. Alanine aminotransferase levels decreased more in high-intensity training than in moderate-intensity training (P = 0.01). Aspartate aminotransferase levels decreased more in moderate-intensity training (P = 0.001) than in high-intensity training (P = 0.03). The effect of high-intensity and moderate-intensity training on gamma glutamine transferase levels was not significant (P = 0.2).Keywords: Non-alcoholic fatty liver, Alanine aminotransferase, Aspartate aminotransferase, Aerobic training, training intensity