EVALUATION OF SERUM LEVELS OF ANTIBODIES AGAINST CHLAMYDIA TRACHOMATIS IN THE WOMEN WITH RECURRENT MISCARRIAGE REFERRED TO THE PERINATOLOGY CLINIC OF SHAHID MOTAHARI HOSPITAL IN URMIA CITY, IRAN

Since chlamydia trachomatis causes chronic infection of female urinary-genital tracts, it may play an effective role in in the occurrence of recurrent miscarriages. This study aims to determine the serum level of antibodies against Chlamydia trachomatis in women with recurrent miscarriages.

The present study is descriptive-analytical and cross-sectional. 76 patients diagnosed with recurrent miscarriages referred to the perinatology clinic of Shahid Motahari Hospital in Urmia, Iran were included in the study. The data was collected using a researcher-made checklist which its validity was approved by the women's group's professors and its reliability was obtained using Cronbach's alpha coefficient of 0.88. Chi-square test was used for analysis of qualitative and independent t-test for analysis quantitative variables. Data analysis was done using SPSS20 software. The significance level was considered less than 0.05.

All 76 patients had positive values for IgG and IgM, and 89.48% of them had positive values of IgA antibodies against Chlamydia trachomatis. There was no significant relationship between the number of abortions, duration of the marriage, gestational age, use of contraceptive pills, and the serum level of antibodies against Chlamydia trachomatis (P>0.05). IgA against this organism in the women with a previous history of successful pregnancy was significantly higher than the women without it (P=0.01).

The positivity of all patients with a history of recurrent miscarriage in terms of serum IgG and IgM levels as well as their predominant positivity in terms of IgA indicates the impact of this infection on the abortion process in the patients.