Voltammetric Electrochemical Sensor for Rapid and Convenient Morphine Detection: A Review

Morphine is a non-synthetic narcotic that derived from opium; it is used for the treatment of pain and it is toxic during overdose or when abused. In comparison to conventional analytical techniques, like HPLC, electroanalytical methods have advantages like simplicity, ease of operation, and miniaturization. Today, electroanalytical sensors are used in agriculture, food, oil, and biomedical applications. In addition to the versatility of reporting signals, such as voltages, currents, power outputs, or electrochemical impedances, electrochemical sensing has low theoretical detection limits due to differences between Faradaic and non-Faradaic currents. In this review, different electrochemical sensing modification-based techniques for determining the morphine content of samples have been investigated. Furthermore, we present the performance of reported electrochemical sensors toward morphine detection, including their detection range (LDR), detection limit (LOD), and modification of electrodes. It is our belief that the information in this manuscript can serve as a platform for future research on developing sensitive electrodes for morphine and other drugs.