The Study of Changes in Oxidative Stress-Cardiac Antioxidants Following the Use of Tribulus Terrestris Extract and Crocin After One Session of Exhaustive Exercise in the Heart Tissue of Elderly Male Rats

 This study aimed to evaluate the changes in cardiac oxidative stress-antioxidants following the use of tribulus terrestris extract and crocin after exhaustive exercise in the heart tissue of elderly male rats.  In this study, elderly male Wistar rats with an average weight of 300 g and an age range of 14 to 18 months were used as the statistical population. A total of 56 rats were selected as a statistical sample and randomly divided into seven groups of 8, including control, exhausting exercise, exercise + crocin dose of 50 mg, exercise + crocin dose of 100 mg, exercise + thrush dose of 100 mg, exercise + thrush dose of 200 mg, exercise + tortoises were divided into 400 mg doses.  The results showed that GPX concentration in training groups with doses of 50 and 100 crocin was significantly higher than in the vulnerable training group (p<0.05). In addition, GPX concentration was significantly higher in the groups with 50 and 100 doses of crocin than in the exercise groups with 100 and 200 doses of thistle (p<0.05). GPX was significantly higher in the exercise group and crocin 100 than in the exercise group and thrush 400 (p<0.01). The results also showed that SOD concentration in training groups with doses of 50 and 100 crocin was significantly higher than  in the specific exercise group (p<0.01). SOD concentration was significantly higher in the exercise groups with 50 and 100 doses of crocin than in the groups with 100 and 200 doses of thistle (p<0.05). Also, SOD was significantly higher in the exercise group and crocin 100 than in the exercise group and thrush 400 (p<0.017).  Therefore, using of antioxidants is recommended to improve heart tissue function in the elderly.