Evaluation of anticandidiasis efficacy of secondary metabolites extracted from Dianthus caryophyllus L. flower buds

The present study was conducted to investigate the effect of crude terpenoid, flavonoid, and alkaloid extracts from flower buds of Dianthus caryophyllus L. against Candida species isolated from different clinical samples such as mouth and vagina in Babil Province during 2021 in Iraq. Antifungal activity was achieved in vitro using agar well diffusion method against Candida species by preparing three concentrations for each crude compound (25, 50 and 100 mg mL-1) and compared with positive control represented by Fluconazole (50 mg mL-1) and negative control represented by 10% dimethyl sulfoxide. The aim of this study was to control Candida species isolated from different clinical samples such as mouth and vagina using secondary metabolites extracted from flower buds of Dianthus caryophyllus L. According to the data collected from the study, the crude terpenoids and flavonoids extracted from flower buds of Dianthus caryophyllus L. exhibited significant superiority at p < 0.05 over the fluconazole when applied to Candida species especially at 100 mg mL-1. Finally, it can be concluded that flower buds of Dianthus caryophyllus L. is most effective in controlling Candida species, especially its terpenoid and flavonoid compounds.