The relationship between anti-mullerian hormone and ovarian response and fertility outcome in infertile women undergoing assisted reproductive techniques (ART) and IUI

Anti-Mullerian Hormone (AMH) is related to woman's age, the number of antral follicles, and the outcome of assisted reproductive techniques. The present study was performed with aim to evaluate the relationship between anti-mullerian hormone levels and ovarian response and pregnancy outcomes in infertile women undergoing assisted reproductive techniques (ART) and IUI.

This cross-sectional (descriptive-analytical) study was performed on 186 infertile women undergoing ART referred to Besat Hospital Infertility Center, Sanandaj, Iran during 2016-2020. Demographic information, FSH level, AMH level, number of gonadotropin injections, number of antral follicles and number of fetuses were evaluated and recorded in the questionnaire.. Also, pregnancy outcomes including abortion, fetal death, fetal malformation and birth were determined and recorded in the questionnaire. Data were analyzed by SPSS software (version 22) and chi-square, Fisher exact, one-way analysis of variance and Pearson correlation. P<0.05 was considered statistically significant.

The mean of anti-mullerian hormone level was 4.0±3.0 (range of 0.1 to 12 ng / ml) and the mean of FSH level was 6.1±2.5 (range of 0.6 to 12.7 IUI / L). There was a significant relationship between anti-mullerian hormone level with the number of ovarian follicles, number of injected HMG, number of eggs retrieved, total number of embryos (P <0.05). There was no significant relationship between anti-mullerian hormone levels with abortion, fetal death, live birth and neonatal malformations (P >0.05).

Determination of AMH levels can help for administration of gonadotropins, prediction of antral follicle numbers, number of eggs retrieved and number of embryos obtained, but Anti-mullerian hormone levels are not associated with pregnancy outcomes.