Review on Pathogenicity and Drug-Resistance Mechanisms at Acinetobacter Baumannii

Acinetobacter baumannii is a gram negative and it is one of the most important and drugresistance infections in hospitals.After Staphylococcus aureus and Pseudomonas aeruginosa, Acinetobacter baumannii is one of the included multidrug resistance infectious bacteria. The aim of this study is to review of pathogenesis and drug-resistance mechanisms in Acinetobacter baumannii.

Methods and Materials:

 International scientific databases including PubMed, Scopus and google scholar were used to review the articles. Out of the 150 articles obtained, only 105 of them with full text have been used in the study. Moreover, articles with abstracts and those received money were excluded from the study.

The rate of drug resistance is growing by examining the scientific papers in most countries of the world. This bacterium gained a specific mechanism of resistance which is a cause of global concern for this organism. Beta-lactamase enzyme producing genes such as OXA, TEM and others are widespread.

In less developed countries, with the indiscriminate use of antibiotics in the society and, in most cases, without the cultivation of pathogenic agents, it causes the emergence and acquisition of resistance genes by the organism. It is recommended that doctors in the hospital request microbial culture from infected samples before treating hospitalized patients in order to prevent resistance as much as possible.