New n-substituted itaconimide polymers: synthesis, characterization and biological activity

In this study, new Itaconimide derivatives were synthesized. A new heteropolymers (PD6, PD7 and PD8) were synthesized under nitrogen from three Itaconimide derivatives [D3-D5] in presence of Benzoyl peroxide initiator. Three drugs (Paracetamol, Carbamazepine, and Trimethoprim) carried on Itaconimide with 3-aminobenzoic acid and triethylamine. FT-IR, 1H-NMR, 13C-NMR, and C.H.N.S were used to analyze all of these monomers and polymers. For heteropolymers (PD6, PD7, and PD8), controlled drug release and swelling percent were investigated at pH=2 and pH=8.0. For these polymers, intrinsic viscosities were determined and used to determine solubility. For the synthesized polymers, the in vitro thiazolyl blue tetrazolium bromide (MTT) reduction test was examined in breast cancer cell line (MCF7), in addition to the physical characteristics and anti-bacterial activity. The results displayed increases the activity towards bacteria for synthesized compounds compared to the Carbamazepine, Paracetamol, and trimethoprine drugs. The controlled drug release and swelling % was studied in different pH values at 37 ºC. Ostwald viscometers were used to quantify intrinsic viscosities at 25 oC and apply the solubility characteristic to these polymers.