The Effect of Aerobic Exercise Training with Stevia Supplementation on Plasma Fetuin b, Pentraxin 3 and GDF-15 and Insulin Resistance in Type 1 Diabetic Rats

Diabetes is one of the main causes of death in developing countries. One of the ways to prevent diabetes and its complications is to do physical activity and use antioxidant supplements. The aim of this study was to investigate the effect of aerobic training and stevia on fetuin b, pentraxin 3 and GDF-15 in plasma and insulin resistance in type 1 diabetic rats. For this purpose, 25 type 1 diabetic mice were divided into 5 groups: healthy control, diabetes control, supplemental diabetes, training diabetes, and training-supplement diabetes. The training program of the rats was for a period of 65 days, with a speed of 20 to 30 m/min and an intensity of 10-25 m/min. Stevia dosage was 250 mg per kilogram of body weight by gavage. Mice were killed 48 hours after the last training session and blood sampling was done. To compare between groups, one-way ANOVA and Bonferroni's post hoc test were used. Examining the changes between groups showed that there is a significant difference between the groups for fetoin b, pentraxin 3 and plasma GDF-15 (p < 0.001). Examining the changes between groups showed that fetoin B and GDF-15 had a significant increase and pentraxin had a significant decrease in the healthy group compared to the diabetic group (p < 0.001). Also, there was a significant difference between the diabetes control group and the supplement and exercise groups in all indicators (p < 0.001. The results of the present study showed that aerobic exercise and stevia supplementation can decrease fetoin b and GDF-15 and increase pentraxin 3 in type 1 diabetic rats. These improvements were better in the group that took exercise and supplementation at the same time.