Comparing the effects of two resistance training models with Linear and Non- Linear Periodization on muscle strength, fatigue, and quality of life among women with multiple sclerosis

Multiple sclerosis disease (MS) is progressing, especially in women. The present study aimed to determine the effect of eight weeks of resistance training with two types of linear and nonlinear periodized on muscle strength, fatigue, and quality of life in women with MS.

A total of 19 patients with MS were selected and randomly assigned to three groups: nonlinear periodized (NLP) (n=6), linear periodized (LP) (n=5), and control (n=8). Both exercise groups performed resistance exercises three sessions a week for 30-45 minutes per session, with an intensity of 30%-70% of a maximum repetition for eight weeks. The linear group (LP) used a linear loading pattern per week. In contrast, the nonlinear group (NLP) experienced different intensities of training from the fourth week onwards. Two days before and after the training protocol, muscle strength was measured indirectly. Moreover, fatigue was evaluated with a 5-item Modified Fatigue Impact Scale (MFIS-5) and quality of life with a 36-Item Short Form Health Survey (SF-36). The results were analyzed in SPSS software (version 21) using the analysis of the covariance model and Fisher's least significant difference (LSD) post hoc test.

Based on the results, LP and NLP training led to a marked increase in muscular strength )P<0.001) and a significant decrease in fatigue )P=0.020) in MS patients. Nonetheless, no significant difference was observed in the quality of life between research groups )P=0/092). There were no significant differences between LP and NLP in factors, except leg press  (P<0/001).

As evidenced by the obtained results, both LP and NLP training models increased muscle strength and reduced fatigue. Nevertheless, linear resistance training led to greater improvement in the aforementioned factors.