The effect of exercise training and olive oil consumption on the spatial learning, genes expression of the AKT and caspase3 of rats with parkinson's disease

Parkinson's disease is a progressive and destructive disorder of the central nervous system. This study aimed to determine the effect exercise training and olive oil consumption on genes expression of the AKT¸ caspase3 and the spatial learning of rats with parkinson's disease

in this study, 30 rats were divided into 5 groups of 6: healthy control¸ parkinson´s control¸ parkinson´s+olive oil¸ parkinson´s+exercise training¸ parkinson´s+exercise training+olive oil.  The rats were fed 0.4 ml of olive oil daily for 8 weeks. Aerobic training was performed 5 days a week for 30 minutes and at a speed of 11 meters per minute. Resistance exercise begin with %30 of the rat´s weight and it reached %100 of the rat´s weight in the eighth week. The gene expression of AKT and caspase3 was measured through PCR-real time and spatial learning using radial maze. Data analyzed using one-way of variance and Thomhan's follow up test.

Increase in AKT genes expressin, reduced in caspase3 expression and spatial learning improvement significantly observed in exercise training and exercise training+olive oil compared to the parkinson's control group (P<0.05).

exercise training with and without olive oil consumpsion can be effective in improving spatial learning by increasing AKT and decreasing caspase3.