Effects of Lordegan Thyme endophytes on Shigella sonnei and Candida albicans

The aim of this study was to investigate the effects of thyme endophytes belonging to the Lordegan region on Shigella sonnei and Candida albicans.  Thyme components were immersed in 70% ethanol (2 minutes), 3.5% sodium hypochlorite (5 minutes), and 75% ethanol (30 seconds), respectively, and lastly washed with sterile distilled water. Subsequently, they were cultured on YEA and PA medium, and the endophytes were isolated. A total of 8 bacterial endophytes were taken from different parts of the Lordegan thyme plant (stem, leaves, and roots) and examined. The endophytes isolated from thyme were bacilli, coccobacilli, and cocci. Antimicrobial and inhibitory properties of endophytes isolated from Lordegan thyme were studied in two methods structural factors and secretory metabolites of endophytes. The results of this study showed the beneficial effects of thyme endophytes on Shigella sonnei and Candida albicans. Bacterial endophytes isolated from thyme (roots stems and leaves) showed stronger inhibitory effects than the study of secretory metabolites against S. sonnei and C. albicans. In general, thyme could be a good alternative to chemical drugs in the treatment of Candida infections, especially cutaneous mucosal candidiasis, and shigellosis, and can be used in therapeutic cases, food, health, and pharmaceutical industries.