Facile One-pot Synthesis of Diaryl Thiourea Derivatives Catalyzed by Cu(II)-Schiff base/SBA-15

Thiourea derivatives are an important group of chemical compounds that play important roles in agriculture, pharmaceuticals, pesticides, and plant growth regulators. Herein a fast synthesis of 1, 3-diaryl-thiourea derivatives by one-pot multi-component reaction of 2-amino-benzoic acid, aryl isothiocyanate, isocyanide, and carbonyl under solvent free condition using Cu(II)-Schiff base/SBA-15 as a reusable heterogeneous catalyst in high yields was reported. These kinds of catalysts are built from mesoporous silica SBA-15 which was covalently anchored with Cu(II) Schiff base complex. The shorter reaction times, good yields, simple work-up procedure and environmentally friendly conditions are the main advantages of this method compared to the last one. This method is also the first example of synthesizing 1, 3-diaryl-thiourea derivatives by Cu(II)-Schiff base/SBA-15 as an efficient catalyst in solvent-free media which can be valuable to be used or investigated for similar systems. The product was identified by its 1H NMR, Mass and IR spectra, which were compared to those reported previously.