Curcuma Longa May Prevent Endothelial Dysfunction in Rattus Norvegicus Exposed by Soot Particulate through Changes of OxLDL and eNOS Levels

The purpose of this study is to prove the efficacy of Curcuma longa (turmeric) extracts against soot (carbon black)-exposed rats with Ox-LDL and eNOS levels. A total of 30 rats were divided into 5 groups with 6 rats in each group. Negative control group (C-) received no treatment. The positive control group (C+) exposed to soot at a concentration of 1064 mg/m3 for 8 hours. Treatment group T1 was exposed to soot at 1064 mg/m3 for 8 hours + Curcuma longa at 1 mg/kg body weight. T2 group was exposed to soot at 1064 mg/m3 for 8 hours + 2 mg curcuma longa mg/kg body weight, and T3 group were exposed to soot at of 1064 mg/m3 for 8 hours + curcuma longa 3 mg/kg body weight. The result of T3 group had lower Ox-LDL levels and higher eNOS levels, and also the difference was significant (p>0.05) than the C+ group. We conclude that the treatment of rats exposed to 1064 mg/m3 soot particles for 8 hours with Curcuma longa extract at a dose of 3 mg/kg body weight reduced Ox-LDL levels and increased eNOS levels because curcumin from Curcuma longa extract effective to break the chain reaction from lipid peroxidation, inhibit LOX-1 expression, prevent LDL modification into ox-LDL, and decrease coupled eNOS levels that prevent NO and GSH degradation.