Effects of zinc oxide nanoparticles on neuronal response of pyramidal neuron of the CA1 hippocampus in rat model of parkinson's disease

Due to the nano size, zinc oxide nanoparticles (ZoN) easily pass through the blood-brain barrier and can enter the brain cells and have different effects on different parts of the nervous system. In the present study, the effect of zinc oxide nanoparticles on the electrical activity of pyramidal cells in the CA1 region of the hippocampus in Parkinson's disease-like rats has been investigated. In this experimental study, adult male Wistar rats were randomly divided into five groups: Substantia nigra pars compacta (SNc) lesion (the lesions were induced by IP injection of Rotenone 2mg/kg/19day/48h) and four groups of ZoN (lesions plus 0.5, 1, 1.5 and 3 mg/kg ip of ZoN). Spontaneous neural activity was recorded for all groups in the CA1 region of the hippocampus. The obtained results showed that IntraPeritoneal (IP) injection of ZoN (1, 1.5 and 3 mg/kg) decreased neuronal spontaneous activity in the rat model of PD. The current study results suggested that acute IP injection of ZoN decreased neuronal response in the CA1 region of the hippocampal in a rat model of PD.