Complications of Tuberculosis Packs and Iron Chelators in Patients with Thalassemia Major in Mostafa Khomeini Hospital in 2018-19

Thalassemia major (TM) is an inherited hemolytic disease with a high prevalence. Nowadays, no complications have been studied in these patients. Therefore, this study aimed to investigate the complications of tuberculosis packs and iron chelators in patients with TM in Mostafa Khomeini Hospital in 2018-2019.

This cross-sectional study was performed in Mostafa Khomeini Hospital in 2018-2019. All eligible patients' records and necessary information, including age, sex, and periodic tests (cardiac, liver, bone, and hormonal and infectious examinations), were reviewed and collected using a checklist. Data were analyzed using SPSS22 software with a significance level of 0.05.

Enrolled patients were 93 cases with TM. The incidence of osteopenia and osteoporosis (69.9%) was the most common, and the lowest cases were hypogonadism (35.5%), hypothyroidism (9.7%), heart failure (5.4%), hepatitis C (2.2%), and liver failure. Hepatitis B and HIV were not seen in these patients.

Results demonstrated that the highest rate of complications was related to the bony part of the body structure, which is due to the pathophysiology of the disease. The low rates of heart failure and liver failure were because the patients with this level of complications may not survive for long.