Preferential Solvation Analysis of Moxidectin in Water/Alcohol Mixtures

Preferential solvation analysis on experimental solubility data of moxidectin was performed by using Invers Kirkwood-Buff Integrals approach at 298.15 K. Local mole fraction of solvents in solvation shell of moxidectin as well as the extent of preferential solvation by each of solvents were calculated as a function of the bulk mole fraction of binary mixtures of water with methanol, ethanol, isopropanol and ethylene glycol. Results indicate that preferential solvation of moxidectin by water occurs in water-rich regions. Whereas, beyond water-rich regions, moxidectin was preferentially surrounded by alcohols in all binary mixtures studied.