Investigation of the iron oxide magnetic nanoparticles Hyperthermia

Cancer is one of the current, widespread diseases in the world which human beings have tackled over the years. In this study the whole process of hyperthermia was simulated in the “COMSOL” software. The octane base fluid and 〖Fe〗_3 O_4 nanomagnetic particles were used in the simulations. The infusion of nanofluid into the porous medium, nanofluid diffusion in tumor, and production of heat caused by nanomagnetic particles were included. For the selected geometry and by using the fine grid, the nanofluid pressure and concentration as function of time were calculated. The results showed that all the physics were involved and were correctly implemented in the Comsol software. Also, the effect of the magnetic field intensity and it’s frequency, concentration and diameter of the nanoparticles on the temperature distribution inside the tumor has been investigated. The calculations showed that by increasing the magnetic field intensity from 1.2 kA/m to 1.4 kA/m, frequency from 164kHz to 180kHz, concentration of nanoparticles from 1024.29 mol/m3 to 1200 mol/m3 and nanoparticles diameter from 8nm to 11nm the tumoral tissue temperature increased from 48℃ to 54℃, 48℃ to 65℃, 48℃ to 80℃ and 48℃ to 160℃ respectively. The mentioned parameters have a direct effect on the generated heat inside the tumor, but it should be noted that increasing the temperature up to 48 ℃ is suitable and temperatures more than 48 ℃ causes damage in the healthy tissues around the tumor.