the effect of galbanic acid on the prevention of intra-abdominal adhesion after surgery in rat

Abdominal adhesions are a common complication after abdominal surgery that can cause intestinal obstructions, pelvic pain, or infertility. This study was conducted with the aim of investigating the effect of galbanic acid on preventing the formation of intra-abdominal adhesions after surgery in rats.Material &

40 male Wistar rats were randomly divided into 4 groups of 10: after abdominal surgery and induction of adhesion, in the control group: 1cc of distilled water, in the galbanic acid group (GA5):  galbanic acid with a dose of 5mg/kg, in the galbanic acid group (Ga10): galbanic acid with a dose of 10 mg/kg and in the tween group: 0.5 cc of tween (solvent of galbanic acid) was prescribed intraperitoneally for 10 days. After the end of the course, the rats were anesthetized, and the open abdomen and adhesive bands were observed and graded and analyzed with spss software and chi-square test. A tissue sample was removed from the adhesion site and after staining, it was observed under a microscope.

Galbanic acid in doses of 5 and 10 mg/kg significantly reduced adhesion compared to the control and tween groups. Histopathological studies show the beneficial effect of galbanic acid by reducing collagen fibers and fibrocytes.

Galbanic acid with anti-fibrin, antioxidant and anti-inflammatory properties in doses of 5 and 10 mg/kg can prevent intra-abdominal adhesions in rats.