Investigating the Impact of the Presence of Platinum-Bone Heterogeneity on the Dose Received of the Tissue in Proton Therapy Using the Holographic In-terferometry Calorimeter System: Modelling

This study aimed to investigate the effect of tissue-bone heterogeneity on the response of holographic interferometric calorimeter system by using modeling techniques. Interferometric calorimeters were widely used in medical applications for measuring temperature changes during thermal therapies. However, the presence of tissue-bone heterogeneity can affect the accuracy of these measurements. In this study, a computational model was developed to simulate the response of interferometric calorimeters in the presence of tissue-bone heterogeneity. The results show that tissue-bone heterogeneity can significantly affect the accuracy of temperature measurements made by interferometric calorimeters. Therefore, this study highlights the importance of considering tissue-bone heterogeneity when using interferometric calorimeters in medical applications.