Assessment of the Salivary Level of Malondialdehyde in Localized Periodontitis Versus Generalized Periodontitis: An Analytical Cross-Sectional Study

We aimed to compare the salivary level of malondialdehyde (MDA) in localized periodontitis versus generalized periodontitis.

Nineteen healthy participants, 35 cases of generalized periodontitis, and 36 cases of localized periodontitis included in the study. The enzyme-linked immunosorbent (ELISA) assay was used to blindly quantify the amounts of MDA in saliva. Data analyzed using one-way ANOVA and Tukey’s post hoc test via R software.

Ninety subjects completed the study. There was a statistically significant difference among study groups (P < 0.001). The Tukey’s post hoc test showed a statistically significant difference for all pairwise compressions (P < 0.001)

The salivary levels of MDA increase in periodontitis patients. Within limitations of this crosssectional study, it could be concluded that salivary MDA levels may possibly be a potential biomarker to examine oxidative stress in periodontal disease.