The effects of intra-articular injection of vancomycin powder at the end of anesthesia on infection symptoms and hemodynamic status of total knee arthroplasty candidates in the post-anesthesia care unit

  Vancomycin is an antibacterial drug used to treat intestinal infections caused by Clostridium difficile, which can cause bloody or watery diarrhea. Clostridium difficile infections are among the most common infections in patients who have recently taken antibiotics for a long time or have been hospitalized. This drug is also used in the treatment of staph infections that cause inflammation of the small intestine and colon. Vancomycin powder 1 g intraarticular intraoperatively administered during total knee arthroplasty. It was not applied selectively so that an inclusion bias brought on by limited application to certain indications could be disregarded  Vancomycin is bactericidal and works by inhibiting the construction of the cell wall and blocking glycopeptide polymerization. The spectrum of effect of this drug includes many Gram-positive organisms, including those that are resistant to other antibiotics. This drug is effective in infections caused by Staphylococcus epidermidis and Staphylococcus aureus resistant to methicillin. Also, this drug is effective for treating infections caused by streptococcus pneumococcus resistant to penicillin. Intra-articular injections for the treatment of joint problems is a term used to directly inject a drug into the joint with the aim of reducing pain. Corticosteroids (steroids) were the first drugs used for this purpose. Vancomycin is used in limited cases, including in the prevention and treatment of endocarditis and other serious infections caused by gram-positive cocci (such as staphylococcus resistant to penicillins). Oral vancomycin is not effective in the treatment of systemic infections, but it is used orally in the treatment of pseudomembranous colitis caused by antibiotics.