Synthesis and characterization of cyclometalated Pd(II) complex bearing tyrosine: Experimental and theoretical study of interaction with biomacromolecules
Considering the important role of bioactive ligands in designing antitumor complexes, mononuclear C^C-cyclometalated Pd (II) complex containing amino acid, tyrosine, was synthesized and identified using Fourier-transform infrared (FT-IR) and nuclear magnetic resonance (NMR) spectroscopic methods. The interaction of the synthesized mononuclear complex with the biomacromolecules, deoxyribonucleic acid (DNA) and bovine serum albumin (BSA), was studied by UV-Vis absorption and fluorescence emission. Based on the experimental studies, an intercalating mode was proposed for the interaction between the complex and DNA. The UV-Vis absorption and fluorescence emission spectroscopies indicated the high affinity of the complex for BSA binding. Molecular docking calculations revealed that the hydrophobic interactions play important roles in complex – BSA binding.
Palladacycle , Aminoacid , DNA , BSA , Molecular docking
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.