A novel approach for total synthesis of Stemona alkaloid: Tuberostemonamide

Stemona alkaloids, are structurally complex and polycyclic alkaloids, obtained from a novel class of natural plants which are extracted, separated, and purified from Stemonaceae family. They are abundantly and more exclusively obtained from the renowned three classes namely: Stemona, Stichoneuron, and Croomia of monocotyledonous family Stemonaceae. They are structurally distinguished by the presence of a central pyrroloazepine core. By 2019, almost 215 Stemona alkaloids were isolated from nature. More than 80 members already discovered and many more are in pipeline likely to be isolated. Traditionally, their roots have been used for centuries in Chinese medicine for a variety of purposes including (but not limited to): treatment of bronchitis, tuberculosis, pertussis, as well as anti-parasitic agents. By rational comparing and contrasting, the multidimensional bioactivities of Stemona alkaloids specifically stemofoline-type derivatives are the most promising compounds representing many lead structures for further development of commercial agents used in pharmaceutical and chemical industries. Here, to this our total synthesis proposal, we vividly explained step by step the total synthesis procedure to get the Stemona alkaloid: Tuberostemonamide. This renowned Stemona alkaloid has potent pharmaceutical effects in the treatment of different neurodegenerative diseases and inflammatory conditions. For such fascinating future work and robust research scope, we interested to propose and work on a unique and effective total synthetic pathway for the Tuberostemonamide synthesis which can be used in synthetic organic lab. We believe our proposed synthetic process discussed here would be utilized efficiently and give highest possible yield (%).