Efficacy of Diosmin on Post-Hemorrhoidectomy Pain: A Systematic Review of Clinical Trials

Diosmin is effective in inhibiting the inflammatory response pathways and improving the acute and chronic symptoms of hemorrhoids. Very few studies have been conducted in this field, and the effectiveness of this drug in different studies has not been presented in a single study so that it can be used or not used based on its results. Therefore, the present study aims to investigate the effectiveness of Diosmin on pain after hemorrhoidectomy in the form of a systematic review of clinical trial studies.

The present study was a systematic review that was designed and conducted based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) statement. The search was done in SID, Magiran, Embase, PubMed, Cochrane Library, Scopus, and Web of Science databases by following the entry and exit criteria and the keywords such as pain, hemoroide, hemorrhoidectomy, Diosmin, surgery, and post-operative.

824 patients participated in these 4 randomized clinical trial studies (with a high quality). The instrument used to assess pain intensity in all studies was the Visual Analogic Scale. Diosmin tablets were prescribed in two forms: 500 mg (in three studies) and 300 mg (in one study) after hemorrhoidectomy. In three studies, Diosmin tablets led to a reduction in pain intensity after hemorrhoidectomy, and in one study, no significant difference was seen.

The results of our study indicated that the use of 500 mg Diosmin oral tablets can lead to a reduction in pain intensity after hemorrhoidectomy. Due to the lower number of studies, the results of this study should be used with caution.