Investigation of expression pattern of hsa-miR-11181-5p during the course of cardiac progenitor cells differentiation

Cardiovascular diseases (CVDs) are globally the number 1 cause of death. Despite improvement in treatment strategies, heart disorders are strongly increasing. Therefore, identification of new regulatory factors involved in the cardiac differentiation is very important. TRKC receptor, part of the large family of receptor tyrosine kinases, is involved in development of the heart and central nervous system. There are many contradictory functions related to the TRKC gene which might be attributed to the non-coding RNAs located in it. Recently, a novel miRNA, hsa-miR-11181-5p located in TRKC gene, has been reported which is involved in nervous differentiation. MiRNAs are small non-coding RNAs regulating their target genes via mRNA degradation or protein inhibition. The goal of the present study was to investigate the expression pattern of hsa-miR-11181-5p during the course of cardiosphere-derived cells (CDCs) differentiation.