Effect of Aerobic Exercise With Vitamin C on Liver Enzymes and ‎Total Antioxidant ‎Capacity and Malondialdehyde in Rats with ‎Alzheimer's Disease

Statement of the problem: 

The liver is the main organ responsible for metabolic control and metabolic detoxification, which significantly contributes to the clearance of beta-amyloid plaques. 

The present study aimed to investigate the effect of aerobic exercise with a supplement of vitamin C on liver enzymes and total antioxidant capacity (TAC) values in rats with Alzheimer's disease.

This was an experimental and fundamental research with a post-test and a control group conducted on 35 aged male Sprague-Dawley rats. The samples were randomly assigned to five groups (7 cases in each group), including 1) Alzheimer, 2) the healthy, 3) the exercise group, 4) the vitamin C, and 5) the exercise+vitamin C group. Aerobic exercise was continued for eight weeks, Total protein in liver tissue was measured to assess TAC, Malondialdehyde (MDA, alanine aminotransferase (AST), alkane phosphatase (AST), and aspartate aminotransferase (AST) levels.

The values of AST, ALT and ALP, MDA, and TAC in the control group with Alzheimer's disease were significantly higher than those in the healthy control group (P<0.05). After the intervention, AST, ALT, and ALP in the exercise and vitamin C supplement groups were significantly lower than in the non-exercise groups (P=0.001).

Aerobic exercise and vitamin C supplementation are effective in improving liver factors in rats with Alzheimer's disease; however, they have no therapeutic effect on MDA and TAC levels in rats with Alzheimer's.