Comparison of the Effects of Propofol and Midazolam Sedation on Post-dural Puncture Headache

Post-dural puncture headache (PDPH) is a common side effect after spinal anesthesia.

This study aimed to compare the sedative dose of propofol and midazolam in reducing headaches after spinal anesthesia.

In order to conduct this study, 80 candidates for spinal anesthesia were divided into two groups, A and B. Both groups received spinal anesthesia with marcaine. In group A, propofol was infused slowly at a dose of 30 g per minute, and in group B, 1 mg midazolam was injected intravenously. In the two groups, the incidence and intensity of headaches were measured using the VAS pain scale. Data were analyzed using Mann-Whitney and t-tests at a significance level of 0.05.

In this study, 65% (52) were male and 35% (28) were female. There was no significant difference between the two groups in terms of demographic information (P > 0.05). In the propofol group, the incidence and severity of headaches were significantly lower than in the midazolam group (P < 0.01).

This study’s results indicated that administering low-dose propofol as a sedative during spinal anesthesia may be more effective in reducing PDPH than midazolam.