Comparison of mRNA and ncRNA expression profiles in colon cancer patients with system biology approach between 2020 and 2021

A group of cells that divide more than normal tissue is called a cancerous tumor.  In most cases, colon cancer which are lumps of flesh originating from the inner lining of the colon staining from intestinal polyps. Elucidating the regulatory relationships between mRNA and lncRNA can contribute to the regulation pattern of gene expression in malignant colorectal cancer.  In this study, the integration of weight gene co-expression network in malignant tumor was investigated by analyzing expression data from samples of normal and cancer patients.

The data used in this article included lncRNA and mRNA exosomal sequences extracted from Exorbase and GEO database.  The weighted gene co-expression network was used to group genes and find gene groups that have a significant correlation.

In this study, the pathological importance of the groups was classified using the level of expression of the groups.  Between the groups, the green group had the most correlation and significance, and for this reason, it is assumed that they have the top impact on the progression of cancer.

Considering the key genes HSPA1B, PPP2R3B and HSPA1A suggested in this study by comparing healthy and sick people and identifying the difference in gene expression profile, a suitable biomarker can be identified to detect people with colorectal cancer.